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CRC1755: CASCAID
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CRC1755: CASCAID

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  • Research
    • Remission
      • #01 Long-term remission of autoimmune diseases by B cell directed CD19 CAR T cell therapy
      • #02 Resolution of inflammation by B cell directed CAR T cell therapy
      • #03 Understanding IVIg triggered checkpoints leading to remission of autoimmune inflammation
      • #04 Tissue-level determinants of macrophage polarisation and histological healing
      • #05 Checkpoints of T cell tissue egress promoting remission in inflammatory bowel disease
      • #06 Changes in lymph node stromal cells by B-cell depleting therapies in resolution of inflammation
    • Resistance
      • #07 Systemic neutrophil imbalances as indicator and mediator of treatment resistance
      • #08 Mechanisms of CD19+ B cell mediated tissue remodelling as checkpoints in autoimmune- fibrosing disorders such as systemic sclerosis
      • #09 Characterisation of molecular resistance mechanisms against biological therapies in inflammatory bowel diseases
      • #10 Mechanisms of how acetylated proteins contribute to rheumatoid arthritis progression and relapse
    • Relapse
      • #11 Unraveling the role of ACOD1 in gut microbiota-driven relapse mechanisms of rheumatoid arthritis
      • #12 Functional role of TNF- and TNFR-superfamily members in treatment-refractory inflammatory bowel diseases
      • #13 The role of T cell responses in the persistence of systemic inflammation and treatment failure in inflammatory bowel disease
      • #14 Impact of a natural microbiota on gut inflammation and therapy response in IBD
      • #15 Fibroblast signatures associated with relapse of arthritis
    • Central
      • Z01 Integrative tissue profiling, omics data analysis support, and FAIR data management
      • Z02 Central tasks of the Collaborative Research Centre 1755
      • WIKO – IMMUNOVERSE: Designing and evaluating a metaversal playground for science
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Janina R., a lupus patient, gave birth to a child four years after receiving CAR T-cell therapy. Source: private

Pregnancy after CAR T-cell therapy
Digital Health You Can Experience in Rheumatology – From VR to an AI Symptom Checker
Why Diseases Return

Resistance


#07 Systemic neutrophil imbalances as indicator and mediator of treatment resistance


#08 Mechanisms of CD19+ B cell mediated tissue remodeling as checkpoints in autoimmune-fibrosing disorders such as systemic sclerosis


#09 Characterisation of molecular resistance mechanisms against biological therapies in inflammatory bowel diseases


#10 Mechanisms of how acetylated proteins contribute to RA progression and relapse

Friedrich-Alexander-Universität
Erlangen-Nürnberg

Freyeslebenstraße 1
91058 Erlangen
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