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CRC1755: CASCAID
Cellular and Systems Control of AutoImmune Disease
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Research
Overview
Remission
#01 Long-term remission of autoimmune diseases by B cell directed CD19 CAR T cell therapy
#02 Resolution of inflammation by B cell directed CAR T cell therapy
#03 Understanding IVIg triggered checkpoints leading to remission of autoimmune inflammation
#04 Tissue-level determinants of macrophage polarisation and histological healing
#05 Checkpoints of T cell tissue egress promoting remission in inflammatory bowel disease
#06 Changes in lymph node stromal cells by B-cell depleting therapies in resolution of inflammation
Resistance
#07 Systemic neutrophil imbalances as indicator and mediator of treatment resistance
#08 Mechanisms of CD19+ B cell mediated tissue remodelling as checkpoints in autoimmune- fibrosing disorders such as systemic sclerosis
#09 Characterisation of molecular resistance mechanisms against biological therapies in inflammatory bowel diseases
#10 Mechanisms of how acetylated proteins contribute to rheumatoid arthritis progression and relapse
Relapse
#11 Unraveling the role of ACOD1 in gut microbiota-driven relapse mechanisms of rheumatoid arthritis
#12 Functional role of TNF- and TNFR-superfamily members in treatment-refractory inflammatory bowel diseases
#13 The role of T cell responses in the persistence of systemic inflammation and treatment failure in inflammatory bowel disease
#14 Impact of a natural microbiota on gut inflammation and therapy response in IBD
#15 Fibroblast signatures associated with relapse of arthritis
Central
Z01 Integrative tissue profiling, omics data analysis support, and FAIR data management
Z02 Central tasks of the Collaborative Research Centre 1755
WIKO – IMMUNOVERSE: Designing and evaluating a metaversal playground for science
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#03 Understanding IVIg triggered checkpoints leading to remission of autoimmune inflammation
Principal Investigators
Prof. Dr. Falk Nimmerjahn
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